Calcium Alpha- Ketoglutaric Acid Powder

Calcium Alpha- Ketoglutaric Acid Powder – Premium Grade Metabolic Support Ingredient

Shaanxi Nuoyuan Biotech Co., Ltd. proudly offers pharmaceutical-grade Calcium Alpha- Ketoglutaric Acid Powder with a guaranteed purity of 99% tested by HPLC. Our 30,000㎡ ISO 9001 certified plant with 20,000 tonnes yearly processing capacity ensures unrivalled stability and bioavailability.

The rapid degradation of pure alpha-ketoglutaric acid and the need for longevity compounds derived from non-animal sources are two major issues facing the industry that our approach tackles. We provide consistent quality for sports nutrition, anti-aging formulations, and therapeutic metabolic support applications worldwide thanks to our five state-of-the-art HPLC testing equipment and more than 15 years of OEM/ODM experience.

What is Calcium Alpha- Ketoglutaric Acid Powder?

Alpha-ketoglutaric acid (AKG), a critical step in the Krebs cycle for cellular energy production, is produced as a stabilised calcium salt. In an acidic environment, pure AKG rapidly deteriorates due to its extreme instability. This substance has improved gastrointestinal tolerance and shelf stability by binding AKG to calcium.

This white crystalline powder has two functions (CAS No. 71686-01-6, Molecular Formula: C5H4CaO5). It helps remove the ammonia that accumulates after intense exercise by acting as a nitrogen scavenger. Additionally, it is a precursor for the synthesis of glutamine and glutamate, both of which support metabolic health and muscle recovery.

This material is closely linked to cellular longevity processes and epigenetic regulation, in contrast to generic amino acid supplements. Because of this, it is the best component for both therapeutic sports nutrition supplements and biological age reversal formulae.

Certificate of Analysis (COA)

Manufacturing Process Excellence 

Using modified strains of Yarrowia lipolytica yeast cultivated in a glycerol-based medium, our production method begins with biosynthesis. Without the use of nutrients originating from animals, this fermentation process ensures exceptional production and purity.

Following fermentation the alpha-ketoglutaric acid is precipitated as the calcium salt using pharmaceutical grade calcium carbonate (CaCO.sub.3). The process yields product with very high purity (above 99%).

Our 30,000㎡ facility contains modern extraction, concentration and drying equipment. 5 HPLC testing devices assist our quality control team in monitoring each manufacturing step. This means your formulations will be provided with a bioavailable ingredient that is consistently stable and works dependably in challenging production conditions and in premix applications.

Key Benefits and Professional Applications

B2C For Anti-Aging and Longevity Formulations:

The product addresses the ‘Hallmarks of Aging’ by regulation of the mTOR pathway and support of DNA methylation. They are also great for lowering chronic inflammation (inflammaging) and helping to regulate the epigenetic clock, which is great for your consumers looking to reverse biological age. High purity >99% provides safety for long term supplementation.

For Sports Nutrition and Recovery (B2B): 

Elite athletes need quick ammonia detoxification following severe anaerobic activity. This chemical turns ammonia into glutamine, prolonging muscle exhaustion and facilitating protein synthesis. It remains active in the challenging pH environment of the stomach to intestinal transition making it a great choice for after exercise recovery matrices.

For Clinical Metabolic Support (B2B)

Because calcium and AKG are involved in both phosphate binding and bone mineralisation, they are beneficial in medical-grade formulations for kidney health and osteoporosis. In contrast to regular calcium salts, the material is immediately integrated into metabolic pathways and improves nitrogen balance in those with disorders that cause muscular atrophy.

Quality Certifications You Can Trust

Your regulatory compliance matters to us. Our Calcium Alpha- Ketoglutaric Acid Powder is manufactured under internationally recognized quality systems:

• ISO 9001 Quality Management System Certificate – Ensures consistent production standards and quality control procedures
• HALAL Certification – Meets Islamic dietary law requirements for global Muslim markets
• STAR-K Kosher Certification – Verified kosher production for Jewish dietary compliance
• FDA Registration – Facility registered with the U.S. Food and Drug Administration

Third-party testing services are available upon request to meet your specific market requirements.

Flexible Packaging Solutions

We understand different business needs require different packaging options. Our product is available in:

• 100g food-grade plastic and aluminum foil bag – Perfect for testing and formulation trials
• 1kg food-grade plastic sacks and aluminum foil bag – Ideal for trial orders and R&D projects
• 5kg food-grade plastic sacks and aluminum foil bag – Suited for medium-quantity production runs
• 10kg food-grade plastic packs and aluminum foil bag – Designed for bulk trial orders
• 25kg/fiber drum – Our primary commercial package for large-scale manufacturing

All packaging meets international shipping standards and protects product stability during transportation.

Global Transportation Methods

We partner with leading logistics providers to ensure your product arrives safely and on time:

• Express Services (DHL, FedEx, UPS, EMS, USPS) – Fast delivery for urgent orders and samples
• Air Cargo – Suitable for large commercial shipments requiring quick transit
• Sea Cargo – Cost-effective solution for bulk commercial shipments
• DDP Air and DDP Sea Options – Delivered Duty Paid services available for hassle-free customs clearance

We have goods on hand all year to help provide quick response and reduced lead times. We provide samples and small-kilogram trial orders, and our business MOQ is just 25kg.

Warehouse & Shipping

Our Teams

Exhibitions

FAQ

Q: What differentiates your product from other AKG products?

A: Our product is HPLC verified for 99% purity and provides increased stability and bioavailability. The calcium-bound version avoids quick breakdown and reduces gastrointestinal discomfort associated with free-form AKG.

Q: Do you have bespoke formulations using this ingredient?

A: Yeah! We have 15 years OEM/ODM expertise and provide custom formulation, private label and full product development services from idea to market.

Q: What certifications do you provide with each shipment?

A: Each batch comes with a Certificate of Analysis (COA), ISO 9001, HALAL, and STAR-K Kosher certifications, and the FDA registration papers. Third party testing available on request.

Q: What is the minimum order quantity ?

A: Sample orders and modest trial orders are welcomed. Our commercial MOQ is 25kg, giving flexibility for new product development.

Q: How do you ensure consistent quality across batches?

A: We have 5 HPLC testing systems at our facilities and thorough quality control in each step of the manufacturing process, from sourcing raw materials to final packing and shipping.

Q: What kind of industries is the product often used in?

A: Its main uses are in sports nutrition supplements, anti-aging goods, metabolic health products, functional foods, and therapeutic nutrition for muscle recovery and bone health.

Contact Us

Ready to enhance your formulations with premium Calcium Alpha- Ketoglutaric Acid Powder? Contact our technical team today at sales@nuoyuanbio.com for samples, quotations, or custom solutions.