Nattokinase Enzyme Powder

Nattokinase Enzyme Powder - Premium Cardiovascular Support Ingredient 

Shaanxi Nuoyuan Biotech Co., Ltd. delivers pharmaceutical-grade Nattokinase Enzyme Powder standardized from 2000FU/g to 60000FU/g, made using sophisticated fermentation technology in our 30,000㎡ ISO 9001-certified plant. Having more than 15 years of experience in OEM/ODM and an annual processing capacity of 20,000 tonnes, we guarantee constant enzyme activity, high purity, and Vitamin K2 below 0.1 ppm, compatible with anticoagulant therapy.

We extensively analyse our product on 5 HPLC systems to validate fibrinolytic efficacy, microbiological purity and compliance for heavy metals. Our ready-stock inventory is available in specifications ranging from trial batches to large commercial orders and provides for rapid delivery by express, air or sea freight to worldwide nutraceutical, pharmaceutical and functional food producers.

What Is Nattokinase Enzyme Powder?

The product is a subtilisin-like serine protease of 275 amino acid residues with a molecular weight of around 28 kDa . It is made by controlled fermentation of non-GMO soybeans using Bacillus subtilis natto under optimised circumstances.

This powerful fibrinolytic enzyme immediately digests fibrin, the protein mesh that forms blood clots, while promoting your body’s natural synthesis of plasmin. Our enzyme formulation provides specific thrombolytic activity, unlike synthetic anticoagulants, and does not affect vitamin K-dependent coagulation factors.

The oral bioavailability, thermal stability up to 50 °C and low cost of manufacturing make this enzyme attractive for pharmaceutical and nutraceutical formulators. The light yellow powder has good solubility in water and the maximum enzymatic activity is maintained around pH 6.0-12.0.

Certificate of Analysis (COA)

Core Production Technology & Quality Advantages

The fermentation is an oxygen-enriched fed-batch process at strictly controlled temperatures (36-37°C) for 24-72 hours. This maximises enzyme output and preserves structural integrity.

The purification is performed in many steps by centrifugation, membrane filtering and chromatographic separation. The final freeze-drying procedure maintains enzymatic potency over the labelled shelf life. Our technological team has removed the typical natto smell, but the whole fibrinolytic activity is still there.

Quality verification is in line with JHFA and JNKA analytical frameworks. Each manufacturing lot is subjected to stringent testing for synthetic substrate fibrin degradation tests, residual solvent screening, and accelerated degradation investigations. We have 5 HPLC systems to assure the batch to batch uniformity and worldwide pharmaceutical standards.

You may be sure that you are developing items for the international market, since you are Halal, Kosher and ISO 9001 certified. Third party testing services may be provided on request to validate requirements for regulatory filings.

Key Benefits and Applications

For Cardiovascular Health Formulations:

Your customers seek natural solutions for maintaining healthy blood circulation. Our enzyme powder breaks down fibrin proteins to support normal blood viscosity and reduce the risk of abnormal clot formation. It's ideal for daily cardiovascular wellness supplements targeting aging populations.

For Sports Nutrition Products:

Post-exercise recovery benefits include improved microcirculation and nutrient delivery to muscle tissues. Formulators incorporate this ingredient into performance recovery blends and endurance support supplements.

For Functional Foods & Beverages:

The enzyme is thermally stable and may be added to fortified beverages, protein bars and health snacks. The neutral taste profile following odour elimination makes it a good fit for consumer-facing items without impacting flavour characteristics.

For Blood Pressure control:

Clinical evidence supports its involvement in modestly lowering blood pressure via vascular support mechanisms. It is a great addition for formulas targeting metabolic syndrome and cardiovascular health.

Important Consideration: This Nattokinase Enzyme Powder ingredient should not be combined with pharmaceutical blood-thinning medications without professional medical consultation. Clear labeling guidance is essential for end-user safety.

Why Choose Nuoyuan's Nattokinase Enzyme Powder?

High-Potency Specifications: Standardised We have a range of enzyme activity levels from 2000FU/g for basic supplements to 60000FU/g for therapeutic formulations. You may choose the precise potency to meet your product positioning and target market needs.

Pharmaceutical-Grade Purity Standards: Our Vitamin K2 elimination procedure provides compatibility with anticoagulant medication. Heavy metals are routinely tested and are within the most rigorous international standards and are compliant with requirements of the EU, FDA and Health Canada.

Fast Turnaround & Reliable Supply Chain: Stock for popular specs throughout the year. Sample orders ship within 2 days. Commercial orders are given priority scheduling of production with delivery dates as low as 7-10 days for expedited shipping.

OEM/ODM Customisation: We provide capsule filling, tablet compression, softgel encapsulation, and bespoke formulation services besides raw powder. Our technical staff helps with turnkey product development with dose optimisation, excipient selection and stability testing.

Global Compliance Documentation: All shipments contain a complete COA, third party test reports, certificate of origin and certification paperwork. We serve your regulatory filing requirements for health claims, new food applications and GMP audits.

International Quality Certificates (IQC)

Certificate of ISO 9001 Quality Management System

Our quality management system is a comprehensive system that encompasses all stages of manufacturing, from raw material acquisition to final product delivery. Compliance with international standards is guaranteed by regular internal audits and continuous improvement procedures.

HALAL Certification

Muslim consumers worldwide trust products bearing our Halal certification. All processing equipment, storage facilities, and handling procedures meet strict Islamic dietary requirements verified by accredited certification bodies.

STAR-K Certification

Jewish dietary law compliance is verified through our Kosher certification program. This certification expands your market reach across North America, Europe, and Israel where Kosher certification is highly valued.

FDA Registration

Our manufacturing facility maintains FDA registration status, demonstrating our commitment to meeting United States regulatory expectations for dietary supplement ingredient production.

Flexible Packaging Options

We accommodate orders from small-scale trials to large commercial shipments:

• 100g food-grade plastic and aluminium foil bag packs – Perfect for initial testing and product development trials
• 1kg food-grade plastic sacks and aluminium foil bag – Ideal for small batch production and market validation runs
• 5kg food-grade plastic sacks and aluminium foil bag – Supports medium-volume manufacturing operations
• 10kg food-grade plastic packs and aluminium foil bag – Suitable for bulk trial orders before committing to full production
• 25kg fiber drum – Our standard commercial package offering optimal protection and storage efficiency

All packaging materials comply with food contact regulations and protect enzyme activity during storage and transportation. Custom packaging solutions are available for private-label partnerships.

Worldwide Transportation Methods

Express Courier Services : For urgent samples and small orders we ship via DHL, FedEx, UPS, EMS and USPS and usual delivery is within 3-7 business days to key markets.

Air Cargo Solutions: Air freight services are used for commercial goods that need speedier delivery. This option is a good compromise between speed and value for orders between 50kg and a few hundred kgs.

For bulk orders, inexpensive ocean freight is ideal for large business shipments. Depending on the quantity of your order and your budget, we may ship FCL (Full Container Load) or LCL (Less than Container Load).

Delivered Duty Paid (DDP) Services Available We provide Delivered Duty Paid (DDP) via air and sea, handling all customs clearance, tariffs and taxes. Your cargo is ready for immediate use, no import processes needed.

All bundling is done to world wide shipping standards, including UN packing regulations for international travel. We provide full shipment paperwork, including business invoices, packing lists, and Certificates of Analysis.

Warehouse & Shipping

Our Teams

Exhibitions

Frequently Asked Questions

Q: How can I choose the enzyme activity level for my formulation?

A: For general cardiovascular support supplements 2000-5000FU/g is good. In premium therapeutic formulations, 20000-40000FU/g are often used. Our technical experts can advise on the optimum potency for your intended dose and product claims.

Q: How stable is the enzyme during tablet compression or encapsulation?Q

A: The enzyme remains active using normal low shear encapsulation methods. For tablets, the use of protecting excipients is recommended. Our R&D team can advise you on formulations for your unique production equipment.

Q: Is it possible to get samples before a commercial order?

A: Yes. Full coas documentation available. 100g sample packets available. Sample orders are usually sent within 48 hours by express courier for fast review.

Q: What is your minimum order quantity for first-time buyers?

A: We may take trial order of 1kg. This lets you assess the quality and do limited production tests before committing to greater quantities.

Q: Do you have supporting documents for various markets and regulations?

A: Yes. We provide full documentation such as allergy, BSE/TSE, GMO-free and other country specific compliance documents to assist with regulatory submissions.

Q: What payment terms do you offer for international orders?

A: We accept T/T, PayPal, and Western Union. For established customers, flexible payment arrangements can be discussed. All transactions are secured and documented with proper invoicing.

Contact Us

Ready to source premium Nattokinase Enzyme Powder for your formulations? Contact our technical sales team at sales@nuoyuanbio.com for quotations, samples, and product development support.