Calcium L-5-methyl Tetrahydrofolate Powder - Premium Active Folate Supplier

Shaanxi Nuoyuan Biotech Co., Ltd. manufactures pharmaceutical-grade Calcium L-5-methyl Tetrahydrofolate Powder with ≥98.0% purity verified by HPLC testing. We have a contemporary 30,000㎡ processing plant producing 20,000 tonnes per year, delivering secure supply chains to worldwide nutrition brands.

This bioavailable folate form avoids the MTHFR enzyme requirements, serving 40-60% of individuals with genetic variations that cannot metabolise synthetic folic acid. Our crystalline Form C has excellent oxidative stability at a regulated moisture level of 8.0-17.0%. Five state-of-the-art HPLC systems continuously check chiral purity (L-isomer >99%), heavy metals (<1ppm) and residual solvents as per ICH Q3C requirements throughout the manufacture.

We have ISO 9001, Halal and Kosher certifications for our quality management systems. We have stock for rapid delivery and provide OEM/ODM comprehensive solution from formulation to private label.

Calcium L-5-methyl Tetrahydrofolate

Calcium L-5-methyl Tetrahydrofolate Powder

What is Calcium L-5-methyl Tetrahydrofolate Powder?

This substance is the calcium salt of L-5-methyltetrahydrofolate, the most abundant physiologically active form of folate found in human plasma. This molecule is incorporated directly into folate metabolic cycles, unlike the synthetic folic acid which requires a four-step enzymatic conversion.

The ingredient tackles major industrial issues. MTHFR gene variations (C677T and A1298C mutations) are present in about half of the world’s population and decrease the efficiency of folic acid conversion by 30-70%. In some people, Unmetabolized Folic Acid (UMFA) builds up in the blood and may negatively impact immune function and hide the signs of a B12 shortage.

These are the hazards our product removes. It directly supports DNA synthesis, methylation processes and homocysteine control without enzymatic bottlenecks. It is thus the ideal source of folate for individualised dietary plans that address genetic diversity.

Technical Specifications & COA

Product name	Calcium L-5-Methyl tetrahydrofolate	Batch number	/
Cas No.	151533-22-1	Batch quantity	6500kgs
Packing	500g/bag	Country of origin	China

Item	Specification	Result
Appearance	White to light yellow crystalline powder	Visual
Odor /Taste	Characteristic	Smell /Taste
Particle size	Through 80 mesh ≥80%, Through 270 mesh ≤3%	Conforms
Crystal Type	C Crystal	Conforms
Identification	The retention time of the major peak in the chromatogram of the sample solution corresponds to that of the reference standard in the assay test	Conforms
	IR	Conforms
	Calcium	Conforms
Calcium L-5-Methyltetrahydrofolate	95.0%~102.0%	99.8%
L-5-Methyltetrahyfolate	≥85.0%	92.2%
Chloride	≤0.5%	<0.004%
D-5-Methylfolate	≤1.0%	0.3%
Boron	≤50μg/g	2.4μg/g
Platinum	≤10μg/g	Not Detected
Arsenic	≤1.5μg/g	Not Detected
Cadmium	≤0.5μg/g	Not Detected
Lead	≤1.0μg/g	Not Detected
Mercury	≤1.5μg/g	Not Detected
4-aminobenzoyl-glutamic acid	≤0.5%	Not Detected
4a-Hydroxy-5-methyltetrahydrofolic acid	≤1.0%	0.1%
(6R)-Mefox (6S)-Mefox	≤1.0%(6R+6S)	0.05%
Tetrahydrofolic acid	≤0.5%	Not Detected
7,8 dihydrofolic acid	≤0.5%	Not Detected
Folic Acid	≤0.5%	Not Detected
5,10-methyltetrahydrofolic acid	≤0.5%	Not Detected
5-methyltetrahydropteroic acid	≤0.5%	0.05%
Dimethyltetrahydrofolic acid	≤0.15%	Not Detected
Individual unknown impurity	≤0.10%	Not Detected
Total impurities	≤2.5%	0.2%
Ethanol	≤5000ppm	186ppm
Acetone	≤5000ppm	119ppm
Isopropyl alcohol	≤5000ppm	Not Detected
Water Content (Karl-Fischer)	6.0% ~ 17.0%	15.0%
Calcium(On the anhydrous and solvent-free basis)	7.0% ~ 8.5%	8.4%
Acerobic bacteria total count	<1000cfu/g	85cfu/g
Mold and yeast count	< l00cfu/g	<10cfu/g
Bile resistance of gram-negative bacteria	<100cfu/g	Not Detected
E.coli	Not Detected/g	Not Detected/g
Staphylococcus aureus	Not Detected/g	Not Detected/g
Salmonella	Not Detected/10g	Not Detected/10g
Conclusion: Conforms to USP-NF 2022 Standard.
Storage: Store in a tight container and dry place at room temperature.

Core Advantages for Your Formulations

Your customers need folate that works immediately. Traditional folic acid fails 30-60% of users due to MTHFR polymorphisms. Our Calcium L-5-methyl Tetrahydrofolate Powder delivers these measurable benefits:

Genetic Compatibility: 100% bioavailability without MTHFR enzyme dependency irrespective of genetics. This immediately boosts the effectiveness of the supplement for your target customers.

higher absorption kinetics : 2-4x quicker peak plasma concentrations than folic acid. Your prenatal formulas provide neural tube protection throughout those important early pregnancy periods when timing really counts.

Good safety profile, no danger of UMFA buildup. This indicates rising customer worries over synthetic vitamin interaction with natural metabolic processes.

Formulation Stability: Crystalline form C remains active when used into multi-ingredient mixes including minerals and other B-vitamins. Independent stability tests indicate <3% deterioration over 24 months at regulated conditions.

Cardiovascular Support Superior Homocysteine decrease to Folic Acid Clinical evidence shows superior homocysteine decrease Your heart health solutions have shown superior biomarker results with less dose needs.

Neurological Function: Crosses the blood-brain barrier effectively, promoting the production of serotonin, dopamine and norepinephrine. This is good for mood support and cognitive health applications.

Core Advantages for Your Formulations

Manufacturing Excellence

Starting with the reduction of folic acid to tetrahydrofolic acid, we continue with regulated methylation processes and follow pharmaceutical-grade synthesis techniques. The essential crystallisation stage is carried out by acetone-induced diastereoselective precipitation under nitrogen environment.

This technique results in stable calcium salt hydrates with regular crystalline forms. Our manufacturing environment is Class 100,000 cleanroom standards with constant environmental monitoring.

We purchase raw materials using rigorous vendor qualification processes. Incoming checks ensure identification, purity and freedom from contaminants before supplies reach manufacturing lines. Batch traceability systems monitor every ingredient from receipt to final packaging.

Quality Control That Saves Your Brand

Your reputation is consistency in your ingredients. These crucial inspections are conducted by our quality assurance team:

Chiral HPLC Analysis: Confirms L-isomer to D-isomer ratios satisfy >99% standard. This avoids the reduction of product effectiveness by inactive stereoisomers.

Related Substances Testing: Monitors degradation products such p-Aminobenzoylglutamate and 5-methyl-5,6-dihydrofolate to ensure purity levels are maintained.

Heavy Metal Screening: ICP-MS technique can identify trace pollutants (Lead, Arsenic, Cadmium, Mercury) with parts-per-billion sensitivity.

Microbial Testing Total Plate Count Yeast, Mould and Pathogen Testing to USP requirements to verify product safety.

Stability Studies: Accelerated and real-time testing according to ICH criteria confirm shelf life claims and storage recommendations.

All test equipment is routinely calibrated and validated. We have 5 HPLC systems for redundancy and cross-verification of important quality parameters.

Certifications You Can Trust

ISO 9001 Quality Management System: An internationally recognised framework for assuring consistent procedures from the acquisition of raw materials to customer delivery.

HALAL Certification: To confirm adherence to Islamic dietary regulations for the Middle Eastern and international Muslim markets.

STAR-K Kosher Certification — Meets rigorous Jewish dietary standards to help you attract Orthodox Jewish consumers.

FDA Registration: We are now registered with the FDA, confirming our dedication to U.S. regulatory compliance.

We are audited yearly by outside parties. We give a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS) and allergies declarations with every shipment.

Certifications

Flexible Packaging Solutions

We understand different business stages require different quantities. Our packaging options accommodate sample testing through commercial production:

100g - Food-grade plastic and aluminum foil bag for initial testing
1kg - Sealed plastic and aluminum foil bag for trial orders
5kg - Medium-quantity plastic and aluminum foil packaging
10kg - Bulk trial order packaging with secure seals
25kg - Fiber drum (primary commercial package) with double-layer protection

All packaging materials are FDA compliant for food contact. Nitrogen flushing and vacuum sealing solutions extend product stability during storage and transit. Private label programs. Custom labelling services provided.

Packaging Solutions

Worldwide Transportation Network

Your deadlines count. We have many delivery options that balance speed and price:

Express Courier (DHL, FedEx, UPS, EMS, USPS): 3-7 days delivery for urgent samples and small orders Includes door to door tracking.

Air Cargo: Cost effective for commercial goods needing 7-15 days travel time. Suitable for orders > 100kgs.

Sea freight: The economical choice for container loads and continuing supply programs. 25-45 days depending on port of destination

DDP Air/Sea: all customs processing, taxes and delivery to your warehouse are handled by us. You get one clear invoice, no hidden fees.

All packing is in line with international shipping regulations of IATA and IMO. We supply full paperwork, including commercial invoice, packing list, certificates of origin and phytosanitary certifications, if applicable.

Minimum Order Quantity: We accept samples and small trial orders. We start commercial orders at 25kg. Contact us for bulk pricing and supply arrangements.

Transportation

Warehouse & Shipping

Our Teams

Exhibitions

Frequently Asked Questions

Q: How is this different from conventional folic acid?

A: It is the active form that your body utilises directly, no enzymatic conversion is required. This makes it useful for those with the MTHFR gene alterations.

Q: How much should I take?

A: The dose used in clinical research for prenatal support is 400-800 mcg/day. Dosages are application specific, therefore check the formulation standards for your individual product.

Q: Does it work with other vitamins?

A: Yes, it is extremely compatible with B complex vitamins, minerals and other nutrients. Our crystalline form is stable in multicomponent compositions.

Q: What is its duration?

A: 24 months if kept in a cool, dry place, away from direct light. We have technical documentation with stability statistics.

Q: Do you make bespoke specs?

A: Okay. OEM/ODM Services: Particle size correction, bespoke mixing and encapsulating. Let us know what you need for custom solutions.

Q: How do you ensure consistent quality?

A: We have five HPLC systems to ensure consistent quality and pharmaceutical grade production and batch to batch testing. We have tested goods in stock for fast dispatch.

Contact Us

Ready to source premium Calcium L-5-methyl Tetrahydrofolate Powder for your formulations? Request samples, technical specifications, or volume quotations today.

Email: sales@nuoyuanbio.com