Hyaluronic Acid Powder Bulk - Premium Quality from Shaanxi Nuoyuan Biotech

Shaanxi Nuoyuan Biotech supplies pharmaceutical and cosmetic-grade Hyaluronic Acid Powder Bulk with a guaranteed purity of 95% Sodium Hyaluronate (HPLC verified), made utilising state-of-the-art microbial fermentation science. Batch quality consistency is monitored by 5 specialist HPLC testing equipment in our 30,000㎡ GMP compliance facility, which processes over 20,000 tonnes of raw materials annually.

(C14H20NNaO11)n is the molecular formula for CAS No. 9004-61-9. With a water absorption rate of 1,000 times its own weight, our white to off-white powder is an exceptional moisture binder. Perfect for use in medical device production, cosmetic formulations, and nutraceutical encapsulation. We have year-round inventory to ensure timely delivery and provide custom molecular weights with flexibility.

Hyaluronic Acid Powder Bulk - Premium Quality from Shaanxi Nuoyuan Biotech

Certificate of Analysis (COA)

Product Name	Hyaluronic acid	Batch number	/
Grade	Cosmetic grade	Batch quantity	5000kgs

Analysis Item	Specification	Test Result
Appearance	White or almost white powder or granule	Visual
Odor /Taste	Characteristic	Smell /Taste
Impurity	None visible impurity	Visual
Glucuronic acid	≥44.5%	45.2%
Sodium hyaluronate	≥92.0%	96.1%
Intrinsic viscosity	Measured value	27.23dL/g
Molecular weight	Measured value	1.80×10⁶
PH	5.0～8.5	6.7
Transmittance(0.5% aq. sol.)	T₅₅_0nm≥99.0%	99.9%
Loss on drying	≤10.0%	7.9%
Protein	≤0.1%	0.032%
Lead (Pb)	≤10.0 mg/kg	<10.0 mg/kg
Arsenic (As)	≤ 2.0 mg/kg	<2.0 mg/kg
Cadmium (Cd)	≤ 5.0 mg/kg	<5.0 mg/kg
Mercury (Hg)	≤ 1.0 mg/kg	<1.0 mg/kg
Total Plate Count	≤100cfu/g	Complies
Yeast and Mold	≤ 50cfu/g	Complies
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative
Thermotolerant Coliform Bacteria	Negative/g	Negative
Storage Condition	In an airtight container,protected from light,cold storage 2℃～10℃.

Multi-Industry Applications Solving Critical Formulation Challenges

The product addresses specific pain points across three high-demand sectors:

Cosmetic & Personal Care Formulation

You may use our powder into anti-aging serums, moisturising masks and premium moisturisers. It preserves viscosity stability in pH 5.0–8.0 and shear stress resistance during high-speed homogenisation. Formulators integrate a variety of molecular weights for multi-depth skin penetration from surface hydration to deep dermis moisture retention.

Nutraceuticals and Functional Foods

For automated capsule filling and tabletting, our powder is a viable choice due to its high flowability (tap density 0.2-0.4 g/ml). Joint health supplements and beauty-from-within capsules are ideal uses for it since it can withstand high temperature processing without deteriorating. You can get this ingredient as hard capsules, softgels, or gummies, and it helps with things like synthesising collagen and replacing synovial fluid.

Healthcare Products and Equipment

For ocular viscoelastics and intra-articular injections, you are given very low endotoxin levels (<0.05 IU/mg). Because of the rigorous sterilisation procedures used to produce our Hyaluronic Acid Powder Bulk, we can guarantee that it will remain stable in eye cavities and synovial joints for a long period without losing any of its molecular weight.

The Whole Manufacturing Cycle: From Start to Finish in the Pharmaceutical Industry

We use a regulated four-step procedure in our production:

Stage 1: Microbial Fermentation

Optimised conditions (pH 7.2–7.6, 37°C) are used to produce certain strains of Streptococcus zooepidemicus in sterile bioreactors. The fermentation method permits molecular weight customisation from 10 kDa to more than 2.0 MDa while avoiding issues associated with supply produced from animals.

Stage 2: Removal & Extraction of Cells

Thermal inactivation of the cells after fermentation. The HA molecules are precipitated with ethanol of pharmaceutical grade and dissolved in buffered saline. This process enables preliminary separation from proteins and nucleic acids.

Stage 3: Multi-step purification

Residual proteins are removed to <0.1% by sequential filtering (0.22μm), activated carbon treatment and organic solvent precipitation We test the molecular weight distribution and purity at each step of purification using 5 HPLC systems to confirm batch-to-batch uniformity.

Stage 4: Spray Drying & Quality Assurance

The filtered solution is then spray dried at low temperature to maintain molecular integrity. The final powder is screened via 80 mesh screens and thoroughly tested for HPLC assay, endotoxin assay, heavy metal assay, microbiological limits assay before to warehouse release.

Technical Benefits of Hyaluronic Acid Powder Bulk

Exact Control of Molecular Weight

You may define specific MW ranges (Oligo <3kDa, Low 3-100kDa, Medium 100kDa-1.0MDa, High 1.0-3.0MDa) to suit your formulation needs. Each batch has MW distribution charts validated by gel permeation chromatograph.

Better storage stability

Our hygroscopic powder is stable for 24 months at 2-8 °C in sealed condition. The dry format decreases shipment weight by 95% compared with pre-dissolved solutions, thereby reducing your transportation expenses.

Regulatory Compliance Documents

Every shipment is supported with comprehensive documentation including CoA with test findings relevant to the batch, allergy statements, GMO-free declarations, BSE/TSE certifications and regulatory support files for FDA DMF, EU Cosmetic Product Safety Reports and Health Canada filings.

Flexible Order Quantities

Unlike competitors requiring 500kg minimums, you can order from 100g sample packs for R&D testing, 1kg for pilot batches, up to 25kg fiber drums for commercial production—all maintaining identical quality standards.

Technical Benefits of Hyaluronic Acid Powder Bulk

International Quality Certifications

Our manufacturing facility holds three critical certifications ensuring global market access:

ISO 9001 Quality Management System

Certified since 2015, our QMS covers all production stages from raw material qualification through final product release. Annual audits verify continuous compliance with international quality standards.

HALAL Certification

Issued by recognized Islamic authorities, confirming our Hyaluronic Acid Powder Bulk meets Shariah requirements. The fermentation-based production process uses no animal-derived materials, making it suitable for Muslim-majority markets.

STAR-K Kosher Certification

Supervised manufacture in accordance with the Jewish dietary regulations. STAR-K rabbinical visits quarterly to check origins of ingredients, cleanliness of equipment and processing procedures.

FDA Registration

Our facility is registered with the U.S. Food and Drug Administration (Registration Number available upon request) and adheres to Current Good Manufacturing Practices (cGMP) for nutritional supplements and cosmetic ingredients.

International Quality Certifications

Comprehensive Packaging Solutions for Every Order Size

Package Type	Net Weight	Dimensions	Ideal For
Food-grade plastic + aluminum foil bag	100g	10×15 cm	R&D testing, formulation trials
Food-grade plastic + aluminum foil bag	1kg	20×30 cm	Pilot production, small-batch manufacturing
Food-grade plastic + aluminum foil bag	5kg	30×40 cm	Medium-volume orders, multiple SKU testing
Food-grade plastic + aluminum foil bag	10kg	35×50 cm	Bulk trial orders before commercial commitment
Fiber drum (primary)	25kg	Ø38×50 cm	Commercial production, inventory stocking

All packing is triple-sealed using moisture-barrier materials that fulfil UN 3373 and IATA requirements for international delivery. In shipping, inside bags are purged with nitrogen to avoid oxidation.

Comprehensive Packaging Solutions for Every Order Size

DDP Options for International Modes of Transport

Courier Express Services

For orders under 100kg, we ship using DHL, FedEx, UPS, or EMS. Average Delivery Time: 5-7 Business Days to North America/Europe. Available for real time monitoring.

Air Freight for Urgent Business Orders

Consolidated air freight carries 100kg-1,000kg packages We collaborate with large airlines (Lufthansa Cargo, Emirates SkyCargo) to get affordable pricing. Transit time avg 7-10 days door to door.

Sea Freight for Cost-Effective Volumes

Ocean shipment >1,000kg orders saved 40-60% costs. We organise FCL (Full Container Load) or LCL (Less than Container Load) depending on your volume. Standard travel is 25 to 35 days.

DDP (Delivered Duty Paid) Air & Ocean

Select our DDP service to make customs simple. We take care of all duties, taxes & clearances. Your merchandise is delivered straight to your warehouse without any extra paperwork.

All shipments are in compliance with IMDG Code for sea transport and IATA Dangerous Goods Regulations as applicable. Temperature-sensitive logistics for delicate locations.

DDP Options for International Modes of Transport

Warehouse & Shipping

Our Teams

Exhibitions

FAQ

Q: What molecular weight to use for anti-aging serums?

A: Combine Low MW (10–50kDa) for deep penetration with High MW (1.0–1.5MDa) for surface hydration. This "4D approach" considers fine lines at different depths of the skin.

Q: Is your powder soluble in oil-based formulations?

A: HA is soluble only in water. For oil phases, pre-dissolve in glycerin or propylene glycol before emulsifying. Use our lipid coated HA grade (special order).

Q: How can I avoid the clumping while dissolving?

A: Add powder slowly to vortexing water at room temperature. 2-4 hours for complete hydration. Do not expose to temperatures over 50°C to avoid molecular degradation.

Q: Is your product suitable for injectable formulations?

A: Our standard cosmetic grade meets topical use standards. For injectables, request our Pharmaceutical Grade with endotoxin <0.01 IU/mg and sterility testing.

Q: What's your lead time for 500kg orders?

A: Stock items ship within 3 business days. Custom MW specifications require 15–20 days for production and QC verification.

Q: Do you provide stability testing data?

A: Yes. Each batch includes 6-month accelerated stability data (40°C/75% RH). We can conduct custom stability studies under your specific storage conditions.

Contact Us

Ready to evaluate our Hyaluronic Acid Powder Bulk for your next formulation? Request free samples or technical data sheets: sales@nuoyuanbio.com